2013年01月09日

NC6004 論文

どんどん学会で発表して欲しいですね。
http://onlinelibrary.wiley.com/doi/10.1111/cas.12079/abstract

Cisplatin;Head and neck cancer;Micelles;Sentinel lymph node;Drug delivery system
Abstract
Cisplatin (CDDP) has been a key drug for chemotherapy in patients with head and neck squamous cell carcinoma (HNSCC). Nephrotoxicity is one of its adverse reactions that are dose-limiting. To increase its antitumor effects and reduce such toxicity problems, polymeric micelles carrying CDDP (NC-6004) have been developed. This study was designed to evaluate the efficacy and safety of NC-6004 for oral squamous cell carcinoma. In vitro antitumor activity was assayed in 4 oral squamous cell carcinoma cell lines. To investigate the antitumor and nephrotoxic effects of NC-6004, nude mice bearing OSC-19 were administered NC-6004 or CDDP. The in vitro growth-inhibitory effect of NC-6004 was significantly less than that of CDDP. However, both NC-6004 and CDDP showed equivalent antitumor effects in vivo. Mice with CDDP developed renal cell apoptosis; however, those injected with NC-6004 were almost free of renal cell injury. Moreover, in an orthotopic tongue cancer model using OSC-19, NC-6004 reduced the rate of sentinel lymph node metastasis to lower than that with CDDP. In conclusion, considering the potential advantages in terms of noticeable antitumor activity, lymphatic drug delivery, and reduced nephrotoxicity, NC-6004 represents a significant structural improvement in the development of a platinum complex.


posted by 戦うサラリーマン at 10:00| Comment(2) | ナノキャリア 論文 | このブログの読者になる | 更新情報をチェックする
この記事へのコメント
NC6004 論文: ナノキャリア 資産家への道
Posted by 水着 可愛い at 2013年07月11日 19:23
prada
Posted by 海パン ビキニ at 2013年07月22日 17:00
コメントを書く
お名前:

メールアドレス:

ホームページアドレス:

コメント:

×

この広告は180日以上新しい記事の投稿がないブログに表示されております。